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Inflammatory Cytokines in a Sample of Alzheimer's Patients from Rio De Janeiro State

Luiz Felipe Da Silva Figueiredo^1,2*, Creso Almeida², Luciana Silva Rodrigues³, Patricia Maria Lourenco Dutra³ and Jerson Laks²

¹Department of Brazilian Music Conservatory, University in Rio de Janeiro, Rio de Janeiro, Brazil

²Department of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

³Department of Medical Science, Rio de Janeiro State University, Rio de Janeiro, Brazil

Received Date: Oct 21, 2022 / Published Date: Nov 21, 2022

Citation: Figueiredo LFDS, Almeida C, Rodrigues LS, Dutra PML, Laks J (2022) Inflammatory Cytokines in a Sample of Alzheimer's Patients from Rio De Janeiro State. J Alzheimers Dis Parkinsonism 12:556.DOI: 10.4172/2161-0460.1000556

Copyright: © 2022 Figueiredo LFDS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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We carried out an evaluation of a sample of 45 elderly into 2 groups GA(21)=75.9+7.4 years and GC(24)=75.3+7.5 years. We evaluated CDR, MMSE, and CST, Lawton and Brody Scale and one sample of 5 ml of blood for analysis of biomarkers. The data were compared between groups. The results showed higher levels for IL-12, IL-10 and IL-1β for Alzheimer’s disease. IL-10 was correlated with age, CDR and functional capacity and negative correlated with MMSE. The age was correlated with TNF-α, IL-10, IL-4. The CST was correlated with IL-4. We conclude that Alzheimer’s disease changes de immune system with higher inflammatory cytokine and correlated with functional and cognitive capacity impacting the elderly health.

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