天美传媒

Abstract

Toxoplasma gondii (T. gondii) is a globally distributed protozoan parasite capable of establishing lifelong infection in its hosts. While its psychiatric associations have been studied extensively in literature, less attention was given to its strictly neurological effects. This review synthesizes current findings on the neuropathological manifestations of T. gondii, focusing on its mechanisms of entry into the central nervous system (CNS), its direct effects on neural tissue, and the resulting neurological syndromes. Emphasis is placed on toxoplasmic encephalitis, neuroinflammation, seizure pathophysiology, and long-term neurodegeneration. Understanding these mechanisms is critical for improving diagnostic and therapeutic strategies for vulnerable populations, particularly those who are immunocompromised.