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Abstract

Several studies demonstrated that many foods may provide a large number of bioactive peptides into the gastrointestinal tract, as for example, the beta-casomorphin-7, an opioid like peptide produced by casein. Recent studies have established that the production of these opioid peptides is experimentally associated with autism. Autism is a developmental disorder with a possible connection between dietary components and triggering or worsening of symptoms. An altered intestinal permeability might allow absorption of in-completely digested peptides (gluten and casein) that could produce opioid-like activity on the brain, causing significant changes in behaviour. It is also showed ,that phenomenon ,of the formation of the opioid peptides , strongly stimulates intestinal mucin production in ex vivo and in vitro models ,in particularly , these effects were associated with a higher expression of intestinal mucins (gel forming), MUC2, the principal constituent of Gut Protective Layer The Over Expression of MUC 2 ,contrary to what one might think, does not strengthen the intestinal protective layer, but rather tends to altering the continuous layer, in a succession of bubbles, separated by channels, which allow for greater permeability, facilitating the cycle of the opioid peptides and the free radicals The effect is twofold:: inhibition of nerve receptors & formation of, cerebral micronuclei .The purpose of this study is to propose research to evaluate, the biochemical process for inhibit the MUC2 Over �Expression, in autism ,using for example enzyme as the sialidase.

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