Journal of Traditional Medicine & Clinical Naturopathy
天美传媒 Access
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ 天美传媒 Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
天美传媒 Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 1504
Indexed In
- CAS Source Index (CASSI)
- Google Scholar
- Sherpa Romeo
- 天美传媒 J Gate
- Genamics JournalSeek
- RefSeek
- Directory of Research Journal Indexing (DRJI)
- Hamdard University
- EBSCO A-Z
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
Decreased interleukin-4 (IL-4), IL-10 and IgE level of type I hypersensitive mice using scopoloetin isolated from noni fruit (Morinda citrifolia L)
6th International Conference and Exhibition on Traditional & Alternative Medicine
Yufri Aldi, Elliza Nasrul, Yanwirasti, Dian Handayani and Dachriyanus
Fakultas Farmasi, Indonesia
ScientificTracks Abstracts: J Tradi Med Clin Natur
DOI:
Abstract
An in vivo study of the activity of scopoletin isolated from noni fruit (Morinda citrifolia L.) on the level of interleukin-4 (IL-4), IL-10 and IgE in type I hypersensitive male Swiss-Webster mice has been carried out. Scopoletin was isolated from dried noni powder by soxhletation method using dichloromethane, separated by column chromatography using silica gel as stationary phase and n-hexane-ethyl acetate (1:4) as mobile phase, then purified by column chromatography using Sephadex LH20 as stationary phase and methanol as mobile phase. Type I hypersensitive male mice were obtained by ovalbumin sensitization. Animal model were divided into 5 groups: negative control group, positive control group, and scopoletin-treated group (1; 3; and 10 mg/kg). The results showed that scopoletin at doses of 1, 3 and 10 mg/kg decreased the level of IL-4 of type I hypersensitive mice significantly (p<0.01). The scopoletin at the dose of 10 mg/kg decreased the serum level of IL-4, IL-10, and IgE (P<0.01) to the normal level. The ability of scopoletin to decrease IL-4 and IgE concentration of type I hypersensitive mice to its normal state was shown by dose of 10 mg/kg BW (p>0.05), while for IL-10 concentration, the decrease until its normal level was shown by dose of 3 mg/kg BW (p<0.05).Biography
Yufri Aldi is a Lecturer at the Faculty of Pharmacy, University of Andalas. He completed his PhD in 2013 at Andalas University. His research is in the field of Farmaco-Immunology.
Email: yufrialdi@gmail.com
