ISSN: 2155-952X
Journal of Biotechnology & Biomaterials
天美传媒 Access
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ 天美传媒 Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
天美传媒 Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 3330
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- 天美传媒 J Gate
- Genamics JournalSeek
- Academic Keys
- ResearchBible
- China National Knowledge Infrastructure (CNKI)
- Access to Global Online Research in Agriculture (AGORA)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
In Association with
Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice
12th Euro Biotechnology Congress
Woo-Young Jeon, Mee-Young Lee, In-Sik Shin and Hyeun-Kyoo Shin
Korea Institute of Oriental Medicine, South Korea Chonnam National University, South Korea
Posters & Accepted Abstracts: J Biotechnol Biomater
DOI:
Abstract
Background & Aim: Samsoeum has long been used in Korea and other Asian countries as a traditional medicine to treat various diseases. In this study, we investigated the antiasthma effect of the herbal medicine Samsoeum water extract (SSEW) using an ovalbumin (OVA)-induced asthma mouse model. Methods: BALB/c mice were sensitized by an intraperitoneal injection of OVA and subsequently challenged with nebulized OVA. We investigated the number of inflammatory cells, the production of Th1/Th2 cytokines and chemokine in bronchoalveolar lavage fluid (BALF), histological changes in lung tissue, the infiltration of inflammatory cells and hyperplasia of goblet cells in lung tissue, the levels of immunoglobulinE (IgE) in BALF and plasma and the expression of inducible nitric oxide synthase (iNOS) in lung tissue. Results: Our results indicated that SSEW decreased the accumulation of inflammatory cells (particularly, eosinophil and neutrophil) and regulated the balance in the production of Th1/Th2 cytokines and chemokine in BALF. Moreover, SSEW suppressed the level of IgE in BALF and plasma and inhibited the infiltration of inflammatory cells, hyperplasia of goblet cells and the expression of iNOS in lung tissue. Conclusions: These findings suggest that, because of its anti-inflammatory and antiasthma properties, SSEW may be useful in reducing airway inflammation in the treatment of asthma.Biography
Email: cozy11@kiom.re.kr
