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Two hydroxyphenyl ethyl octalactones from the leaves of Globimetula braunii mistletoe growing on Piliostigma thonningii
Pharma Middle East
Abdullahi Musa Ismail1, Musa Aliyu Muhammad2, Muhammad Kamal Ja芒�?�?afar3, Nasir Tajuddeen4, Idris Abdullahi Yunusa2 and Abdurrahman Yunusa Rafindadi2
1Usmanu Danfodiyo University, Nigeria 2Ahmadu Bello University, Nigeria 3Sheda Science and Technology Complex, Nigeria 4Ahmadu Bello University, Nigeria
Posters-Accepted Abstracts: Clin Pharmacol Biopharm
DOI:
Abstract
Globimetula braunii mistletoe is widely distributed in the tropical countries including Ghana, Cameroun and Nigeria where it is amongst the ingredients of many herbal medicines. The plant is used as a recipe for treating hypertension, rheumatism, epilepsy, infertility, stomach problems, diabetes and as a laxative. Most of these ethno-pharmacological uses have been validated scientifically on the crude extract. Inspite of the considerable information on biological properties of G. braunii mistletoe, there is an acute paucity of data on the secondary metabolites responsible for the observed effects. The ethanolic extract of G. braunii leaves, after successive extraction with various organic solvents gave different fractions and the ethyl acetate portion afforded two new hydroxyphenyl-ethyl octalactones; 4,6-dihydroxy-8-[2-(4-hydroxy-phenyl)-ethyl]-oxocan-2-one and 6-hydroxy-8-[2-(4-hydroxy-phenyl)-ethyl]-5,6,7,8- tetrahydro-oxocin-2-one. The structures of the two isolated compounds were determined by spectroscopic analyses, particularly, the 1 and 2D - NMR. The two compounds isolated in this work might probably, contribute to the observed biological activities and the recently reported anti-convulsant effect exhibited by the ethyl acetate fraction of this plant.Biography
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